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One single, simple starting dose for children ≤11 years
- The same once-weekly schedule as other EHLs, so children and their caregivers can switch with confidence
ALPROLIX® Dosing
ALPROLIX prophy offers flexible dosing options to keep pace with your lifestyle
Convenient starting doses for adults and teens ≥12 years
Flexibility for the unexpected:
- Dosing schedule may be adjusted based on individual response. More frequent or higher doses may be needed, especially in kids under 6 years old
To improve your chances of a single-vial infusion, ALPROLIX offers 6 different sizes
Graphic not representative of actual drug product vials.
Frequently asked questions
Get answers to commonly asked questions about ALPROLIX.
Patient stories
See how real ALPROLIX patients
manage hemophilia B.
manage hemophilia B.
Appropriate adults and teens may be able to extend dosing further
Work with your doctor to see if a 14-day dosing schedule is possible.
It’s freedom and flexibility that may make a difference in your active life.
- 54% of the patients in the B-LONG clinical trials who started with 10-day dosing (at 100 IU/kg) extended dosing to 14 days or longer
- In the B-YOND trial, most people were on individualized prophy beforehand and were well controlled before they began extending their time between doses*
- People in the Kids B-LONG trial were not included in this later analysis
*From a later analysis of 23 people who extended to 14 days or more during the B-LONG and B-YOND trials.
EHL=extended half-life; prophy=prophylaxis.
ALPROLIX on-demand dosing to help resolve unexpected bleeds:
For questions about on-demand dosing, talk to your doctor.
- 30-60 IU/kg for mild-to-moderate bleeds like bruises or nosebleeds
- Repeat every 48 hours until bleeding stops - 80-100 IU/kg for major bleeds like those involving the throat, thigh muscles, or brain
- Consider a repeat dose after 6-10 hours and then every 24 hours for the first 3 days
Always report breakthrough bleeds to your doctor, and ask about the right dose to resolve them.
View a step-by-step video and see how ALPROLIX is prepared and infused
Important Safety Information and Indication
INDICATION
IMPORTANT SAFETY INFORMATION
INDICATION
ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein] is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency. Your healthcare provider may give you ALPROLIX when you have surgery.
IMPORTANT SAFETY INFORMATION
Do not use ALPROLIX if you are allergic to ALPROLIX or any of the other ingredients in ALPROLIX.
Tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, supplements, or herbal medicines, have any allergies and all your medical conditions, including if you are pregnant or planning to become pregnant, are breastfeeding, or have been told you have inhibitors (antibodies) to Factor IX.
Common side effects of ALPROLIX include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.
Allergic reactions may occur with ALPROLIX. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.
Redness to the skin at the injection site may also occur.
ALPROLIX may increase the risk of formation of abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.
Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly.
These are not all of the possible side effects of ALPROLIX. Talk to your healthcare provider right away about any side effect that bothers you or does not go away, or if bleeding is not controlled using ALPROLIX.
Tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, supplements, or herbal medicines, have any allergies and all your medical conditions, including if you are pregnant or planning to become pregnant, are breastfeeding, or have been told you have inhibitors (antibodies) to Factor IX.
Common side effects of ALPROLIX include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.
Allergic reactions may occur with ALPROLIX. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.
Redness to the skin at the injection site may also occur.
ALPROLIX may increase the risk of formation of abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.
Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly.
These are not all of the possible side effects of ALPROLIX. Talk to your healthcare provider right away about any side effect that bothers you or does not go away, or if bleeding is not controlled using ALPROLIX.
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