Interested in Going beyond your 7- or 10-day schedule?

ALPROLIX offers adults and adolescents the flexibility to continue or extend beyond a weekly prophylaxis regimen. Some patients may be able to extend their prophy dosing schedule to 14 days based on their body's response. Here's the story:

If your healthcare team is pleased with the progress of your treatment, you can ask them if you might be able to extend your dosing schedule.

The recommended starting prophylaxis regimens are either 50 IU/kg once weekly or 100 IU/kg once every 10 days. In children ≤ 12 years of age, start at 60 IU/kg once weekly. Dosing regimen can be adjusted based on your body's response.

More frequent or higher doses may be needed in children <12 years of age, especially in children <6 years of age.

Your doctor determines if you’re eligible to adjust your dosing regimen based on your body's response.

More than half of patients in the B-LONG clinical trials who started with 10-day dosing (at 100 IU/kg) extended dosing to 14 days or longer.*

54% of people in the individualized prophy of the B-LONG study extended to ≥14-day dosing. The overall median dosing interval on study was 12.5 days.

In the B-LONG study, the median interval during the last 6 months in 26 subjects who were on study for at least 9 months was 13.8 days. The ability to extend was based on individual patient response.

Learn about these patient journeys with ALPROLIX

Patient stories reflect the real-life experiences of persons diagnosed with hemophilia B who have been prescribed ALPROLIX. However, individual experiences may vary. Patient stories are not necessarily representative of what another person using ALPROLIX may experience.

Casey


Worked with his doctor to extend his dosing schedule.

Watch his story

Casey


Worked with his doctor to extend his dosing schedule.

Watch his story

Alex


Switched from on-demand to prophy.

Watch his story

Alex


Switched from on-demand to prophy.

Watch his story

Brian


Took control of his hemophilia treatment with a once-every-7-day dosing regimen.

Watch his story

Brian


Took control of his hemophilia treatment with a once-every-7-day dosing regimen.

Watch his story

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INDICATION: ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein] is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency. Your healthcare provider may give you ALPROLIX when you have surgery.

important safety information and indication 

IMPORTANT SAFETY INFORMATION
Do not use ALPROLIX if you are allergic to ALPROLIX or any of the other ingredients in ALPROLIX.

Tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, supplements, or herbal medicines, have any allergies and all your medical conditions, including if you are pregnant or planning to become pregnant, are breastfeeding, or have been told you have inhibitors (antibodies) to Factor IX.

Common side effects of ALPROLIX include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.

Allergic reactions may occur with ALPROLIX. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.

Redness to the skin at the injection site may also occur.

ALPROLIX may increase the risk of formation of abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.

Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly.

These are not all of the possible side effects of ALPROLIX. Talk to your healthcare provider right away about any side effect that bothers you or does not go away, or if bleeding is not controlled using ALPROLIX.

INDICATION
ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein] is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency. Your healthcare provider may give you ALPROLIX when you have surgery.

important safety information and indication 

IMPORTANT SAFETY INFORMATION
Do not use ALPROLIX if you are allergic to ALPROLIX or any of the other ingredients in ALPROLIX.

Tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, supplements, or herbal medicines, have any allergies and all your medical conditions, including if you are pregnant or planning to become pregnant, are breastfeeding, or have been told you have inhibitors (antibodies) to Factor IX.

Common side effects of ALPROLIX include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.

Allergic reactions may occur with ALPROLIX. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.

Redness to the skin at the injection site may also occur.

ALPROLIX may increase the risk of formation of abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.

Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly.

These are not all of the possible side effects of ALPROLIX. Talk to your healthcare provider right away about any side effect that bothers you or does not go away, or if bleeding is not controlled using ALPROLIX.

INDICATION
ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein] is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency. Your healthcare provider may give you ALPROLIX when you have surgery.

Please see full Prescribing Information

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Bioverativ Therapeutics Inc.
Waltham, MA 02451 USA
U.S. License #2078

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Questions?

1-855-MYALPROLIX (1-855-692-5776)

Monday-Friday, 8am-8pm, ET

© 2021 Genzyme Corporation. All rights reserved. ALPROLIX is a registered trademark of Bioverativ Therapeutics Inc., a Sanofi company.

MAT-US-2021804-V4.0-10/2021 LAST UPDATED: OCTOBER 2021

© 2021 Genzyme Corporation. All rights reserved. ALPROLIX is a registered trademark of Bioverativ Therapeutics Inc., a Sanofi company.

MAT-US-2021804-V4.0-10/2021 LAST UPDATED: OCTOBER 2021

Questions?

1-855-MYALPROLIX (1-855-692-5776)

Monday-Friday, 8am-8pm, ET