Hemophilia is an inherited bleeding disorder that causes clotting protein factors to be missing or not work properly.
Hemophilia B is different than hemophilia A
Hemophilia A
In hemophilia A, factor VIII is missing
Factor VIII works inside the bloodstream to help stop bleeds
Hemophilia B
In hemophilia B, factor IX is missing
Factor IX travels outside the bloodstream and helps stop bleeds
Factor IX and VIII work differently
Factor IX is different than factor VIII because it moves outside the bloodstream, into places such as tissues, muscles, and joints. This means it has a different factor activity, or pharmacokinetics. Doctors can observe this difference by reviewing specific lab tests.
Patient stories
See how real ALPROLIX patients manage hemophilia B.
In hemophilia B, both your lab test results and your experience will help your doctor determine treatment success
Measuring factor activity is just one part of the puzzle. Monitoring your experience or outcomes is another way your doctor can determine if your factor IX therapy is working.
By reporting things like breakthrough bleeds to your doctor, the two of you can work together to help determine if your factor IX therapy is a success.
Find your CoRe Manager and connect today
Sanofi Hemophilia Community Relations and Education (CoRe) Managers offer education and support to people living with hemophilia and their families, including treatment options and lifestyle tips. Use our CoRe Locator to find the CoRe Manager in your area.
ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein] is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency. Your healthcare provider may give you ALPROLIX when you have surgery.
Important Safety Information
Do not use ALPROLIX if you are allergic to ALPROLIX or any of the other ingredients in ALPROLIX.
Tell your healthcare provider if you have or have had any medical problems, take any medicines, including prescription and non-prescription medicines, supplements, or herbal medicines, have any allergies and all your medical conditions, including if you are pregnant or planning to become pregnant, are breastfeeding, or have been told you have inhibitors (antibodies) to Factor IX.
Common side effects of ALPROLIX include headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system.
Allergic reactions may occur with ALPROLIX. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.
Redness to the skin at the injection site may also occur.
ALPROLIX may increase the risk of formation of abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.
Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly.
These are not all of the possible side effects of ALPROLIX. Talk to your healthcare provider right away about any side effect that bothers you or does not go away, or if bleeding is not controlled using ALPROLIX.
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