Having a chat with your doc?

Make the next move in your treatment journey and start a conversation with your healthcare team about ALPROLIX. Considering a switch to ALPROLIX? We have a downloadable discussion guide to help you confidently ask the right questions and get the answers you need to make the choice that's right for you.

If you're already on ALPROLIX, we have info to help you, too.

I’m thinking of
switching to ALPROLIX

I’m currently

Thinking about a move to ALPROLIX? Think about doing these things first.

Get the most from facetime with your doc

We've put together a helpful guide that can help you make the most out of your next doctor's appointment. Have a productive conversation about the direction you want to take your treatment:

Download guide

Make sure you're prepared with any questions you need answered.

Know why you're thinking of switching to ALPROLIX, and write that on your guide as well.

Remember, be your own advocate.

Know your stuff

There are terms your doctor might use when discussing treatment, terms you should be acquainted with before you get there.

Extended Half-life

There are hemophilia therapies available designed to extend the half-life of the medicine in your body. ALPROLIX was designed this way to allow for fewer infusions with extended protection from bleeds.


While some proteins can be broken down very quickly, research shows Fc Fusion allows ALPROLIX to use your body’s natural pathway to recycle and recirculate in the bloodstream longer.

Annual Spontaneous Bleed Rates

Internal and external bleeding episodes that occur without an obvious cause are called spontaneous bleeds. The number of these bleeds that a person with hemophilia gets in a year is referred to as their Annual Spontaneous Bleed Rate or AsBR. People infusing prophylactically with ALPROLIX have been shown to experience a median of 1 AsBR per year.*

Talk about dosing

When your doctor agrees that a switch to ALPROLIX is right for you, your recommended starting dosing schedule will more than likely be 7 or 10 days. ALPROLIX is the only Factor IX treatment with two starting doses: 50 IU/kg every 7 days or 100 IU/kg every 10 days. But ask your doctor about extending. You may be able to work with him or her to extend your dosing schedule to 14 days or longer.

*54% of people in the individualized prophy arm extended to ≥14-day dosing. The overall median dosing interval on study was 12.5 days. The median interval during the last six months in 26 subjects who were on study for at least nine months was 13.8 days.

†The recommended starting prophylaxis regimens are either 50 IU/kg once weekly, or 100 IU/kg once every 10 days. Dosing regimen can be adjusted based on individual response.

Children under 12 years of age may have higher Factor IX body weight-adjusted clearance, shorter half-life, and lower recovery. Higher dose per kilogram body weight or more frequent dosing may be needed.







We'd like to send you helpful information on hemophilia B and ALPROLIX from time to time. If you're still considering ALPROLIX we'll send you a Bluetooth® speaker to listen to patient stories or if you're already on ALPROLIX, a cooler bag for factor.

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indications and important facts about alprolix 

What is the most important information i should know about ALPROLIX® [Coagulation Factor IX (Recombinant), Fc Fusion Protein]? You should not use ALPROLIX if you are allergic to ALPROLIX or any of the other ingredients in ALPROLIX. Tell your healthcare provider if you have had an allergic reaction to any Factor IX product prior to using ALPROLIX.
Allergic reactions may occur. Call your healthcare provider or get emergency treatment right away if you have any of the following symptoms: hives, chest tightness, wheezing, difficulty breathing, or swelling of the face.

ALPROLIX may increase the risk of forming abnormal blood clots in your body, especially if you have risk factors for developing blood clots. Call your healthcare provider or seek emergency care if you have symptoms of a possible abnormal blood clot, which may include: chest pain, difficulty breathing, unexpected swelling of an arm or leg with or without pain or tenderness.

Your body can also make antibodies called "inhibitors" against ALPROLIX, which may stop ALPROLIX from working properly. Your healthcare provider may need to test your blood for inhibitors from time to time.

THE MOST COMMON SIDE EFFECTS OF ALPROLIX INCLUDE: headache, abnormal sensation in the mouth, and pain in your side with blood in your urine, which may be a sign of clot formation in the urinary collecting system. These are not all the possible side effects of ALPROLIX. Talk to your healthcare provider for more information and about any side effect that bothers you or does not go away.


Tell your healthcare provider about all your health conditions, including if you:

  • Have or have had any medical problems.
  • Are taking any prescription and non-prescription medicines, such as over-the-counter medicines, supplements, or herbal medicines.
  • Are pregnant or planning to become pregnant. It is not known if ALPROLIX may harm your unborn baby.
  • Are breastfeeding. It is not known if ALPROLIX passes into breast milk or if it can harm your baby.
  • Have been told that you have inhibitors to Factor IX (because ALPROLIX may not work for you).


If your bleeding is not controlled and you experience a lack of clinical response to Factor IX therapy, call your healthcare provider right away.

Medicines are sometimes prescribed for purposes other than those listed here. Do not use ALPROLIX for a condition for which it was not prescribed. Do not share ALPROLIX with other people, even if they have the same symptoms that you have.


ALPROLIX is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital Factor IX deficiency.

Your healthcare provider may give you ALPROLIX when you have surgery.


ALPROLIX should be administered as ordered by your healthcare provider. You should be trained on how to do infusions by your healthcare provider. Many people with hemophilia B learn to infuse ALPROLIX by themselves or with the help of a family member. See the booklet called "Instructions for Use" packaged in your ALPROLIX for directions on infusing ALPROLIX. If you are unsure of the procedure, please ask your healthcare provider.


Please read this information carefully before using ALPROLIX and each time you get a refill, as there may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.


The risk information provided here is not comprehensive. To learn more, talk about ALPROLIX with your healthcare provider or pharmacist.
The FDA-approved product labeling can be found at www.alprolix.com or 1-855-MyALPROLIX (692-5776).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.


Bioverativ Therapeutics Inc.
Waltham, MA 02451 USA
U.S. License #2078

Please see Full Prescribing Information


1-855-MYALPROLIX (1-855-692-5776)

Monday-Friday, 8am-8pm, EST

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© 2019 Bioverativ Therapeutics, Inc., an affiliate of Sanofi. All rights reserved.


© 2019 Bioverativ Therapeutics, Inc., an affiliate of Sanofi. All rights reserved.



1-855-MYALPROLIX (1-855-692-5776)

Monday-Friday, 8am-8pm, EST